CD81

CD81
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1G8Q, 1IV5, 3X0E, 5DFW, 5DFV
Tanımlayıcılar
Başka adlar	CD81
Dış kimlikler	OMIM: 186845 MGI: 1096398 HomoloGene: 20915 GeneCards: CD81
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	2,397,397 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• GO:0001948, GO:0016582 protein bağlanması; • MHC class II protein complex binding; • transferrin receptor binding; • virus receptor activity; • integrin binding; • cholesterol binding; • lipid binding;
Hücresel bileşeni	• integral component of membrane; • Vezikül; • membrane; • focal adhesion; • integral component of plasma membrane; • immunological synapse; • extracellular exosome; • Hücre zarı; • basolateral plasma membrane;
Biyolojik süreci	• positive regulation of 1-phosphatidylinositol 4-kinase activity; • GO:0034613 protein localization; • regulation of protein stability; • receptor internalization; • cellular response to low-density lipoprotein particle stimulus; • regulation of cell motility; • receptor-mediated virion attachment to host cell; • protein localization to lysosome; • cell surface receptor signaling pathway; • positive regulation of B cell proliferation; • positive regulation of cell population proliferation; • regulation of immune response; • positive regulation of peptidyl-tyrosine phosphorylation; • Viral giriş; • positive regulation of protein catabolic process in the vacuole; • cell population proliferation; • GO:0022415 viral process; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of complement activation; • humoral immune response mediated by circulating immunoglobulin; • protein localization to plasma membrane; • adaptive immune response; • immune system process;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	975
	12520
	ENSG00000110651
	ENSMUSG00000037706
	P60033
	P35762
	NM_001297649; NM_004356
	NM_133655
	NP_001284578; NP_004347
	NP_598416
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

CD81 molekülü, ayrıca 81. Başkalaşım Kümesi olarak da bilinir, insanların 11. kromozomunda yer alan CD81 geni tarafından kodlanan bir proteindir.^[4]^[5]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110651 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD81 CD81 molecule". 13 Nisan 2010 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024.
^ Andria ML, Hsieh CL, Oren R, Francke U, Levy S (August 1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". Journal of Immunology. 147 (3). ss. 1030-6. doi:10.4049/jimmunol.147.3.1030. PMID 1650385. 5 Eylül 2004 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024.

Ek okuma

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Andria ML, Hsieh CL, Oren R, ve diğerleri. (1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". J. Immunol. 147 (3). ss. 1030-6. doi:10.4049/jimmunol.147.3.1030. PMID 1650385.
Oren R, Takahashi S, Doss C, ve diğerleri. (1990). "TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins". Mol. Cell. Biol. 10 (8). ss. 4007-15. doi:10.1128/MCB.10.8.4007. PMC 360911 $2. PMID 1695320.
Levy S, Nguyen VQ, Andria ML, Takahashi S (1991). "Structure and membrane topology of TAPA-1". J. Biol. Chem. 266 (22). ss. 14597-602. doi:10.1016/S0021-9258(18)98728-4. PMID 1860863.
Takahashi S, Doss C, Levy S, Levy R (1990). "TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen". J. Immunol. 145 (7). ss. 2207-13. doi:10.4049/jimmunol.145.7.2207. PMID 2398277.
Matsumoto AK, Martin DR, Carter RH, ve diğerleri. (1993). "Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes". J. Exp. Med. 178 (4). ss. 1407-17. doi:10.1084/jem.178.4.1407. PMC 2191213 $2. PMID 7690834.
Nagira M, Imai T, Ishikawa I, ve diğerleri. (1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression". Cell. Immunol. 157 (1). ss. 144-57. doi:10.1006/cimm.1994.1212. PMID 8039242.
Virtaneva KI, Emi N, Marken JS, ve diğerleri. (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins". Immunogenetics. 39 (5). ss. 329-34. doi:10.1007/BF00189229. PMID 8168850.
Radford KJ, Thorne RF, Hersey P (1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochem. Biophys. Res. Commun. 222 (1). ss. 13-8. doi:10.1006/bbrc.1996.0690. PMID 8630057.
Szöllósi J, Horejsí V, Bene L, ve diğerleri. (1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY". J. Immunol. 157 (7). ss. 2939-46. doi:10.4049/jimmunol.157.7.2939. PMID 8816400.
Berditchevski F, Tolias KF, Wong K, ve diğerleri. (1997). "A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase". J. Biol. Chem. 272 (5). ss. 2595-8. doi:10.1074/jbc.272.5.2595. PMID 9006891.
Berditchevski F, Chang S, Bodorova J, Hemler ME (1997). "Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6". J. Biol. Chem. 272 (46). ss. 29174-80. doi:10.1074/jbc.272.46.29174. PMID 9360995.
Tachibana I, Bodorova J, Berditchevski F, ve diğerleri. (1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. 272 (46). ss. 29181-9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
Hu RJ, Lee MP, Connors TD, ve diğerleri. (1998). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1). ss. 9-17. doi:10.1006/geno.1997.4981. PMID 9403053.
Pileri P, Uematsu Y, Campagnoli S, ve diğerleri. (1998). "Binding of hepatitis C virus to CD81". Science. 282 (5390). ss. 938-41. Bibcode:1998Sci...282..938P. doi:10.1126/science.282.5390.938. PMID 9794763.
Serru V, Le Naour F, Billard M, ve diğerleri. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (Pt 1). ss. 103-11. doi:10.1042/0264-6021:3400103. PMC 1220227 $2. PMID 10229664.
Tachibana I, Hemler ME (1999). "Role of Transmembrane 4 Superfamily (Tm4sf) Proteins Cd9 and Cd81 in Muscle Cell Fusion and Myotube Maintenance". J. Cell Biol. 146 (4). ss. 893-904. doi:10.1083/jcb.146.4.893. PMC 2156130 $2. PMID 10459022.
Higginbottom A, Quinn ER, Kuo CC, ve diğerleri. (2000). "Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2". J. Virol. 74 (8). ss. 3642-9. doi:10.1128/JVI.74.8.3642-3649.2000. PMC 111874 $2. PMID 10729140.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110651 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: CD81 CD81 molecule". 13 Nisan 2010 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024.

[pmid1650385-5] Andria ML, Hsieh CL, Oren R, Francke U, Levy S (August 1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". Journal of Immunology. 147 (3). ss. 1030-6. doi:10.4049/jimmunol.147.3.1030. PMID 1650385. 5 Eylül 2004 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024.

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