AASDHPPT

AASDHPPT
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	2BYD, 2C43, 2CG5
Tanımlayıcılar
Başka adlar	AASDHPPT, AASD-PPT, LYS2, LYS5, CGI-80, aminoadipat semialdehit dehidrojenaz-fosfopanteteinil transferaz
Dış kimlikler	OMIM: 607756 MGI: 1914868 HomoloGene: 9130 GeneCards: AASDHPPT
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	106,098,699 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• transferase activity; • GO:0001948, GO:0016582 protein bağlanması; • magnesium ion binding; • metal ion binding; • holo-[acyl-carrier-protein synthase activity];
Hücresel bileşeni	• sitoplazma; • Sitozol; • extracellular exosome;
Biyolojik süreci	• lysine biosynthetic process via aminoadipic acid; • pantothenate metabolic process;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	60496
	67618
	ENSG00000149313
	ENSMUSG00000025894
	Q9NRN7
	Q9CQF6
	NM_015423
	NM_026276; NM_001326359
	NP_056238
	NP_001313288; NP_080552
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

L-aminoadipat-semialdehit dehidrojenaz-fosfopanteteinil transferaz, insanlarda AASDHPPT geni tarafından kodlanan bir enzimdir.^[4]^[5]^[6]

Bu gen tarafından kodlanan protein, lizin biyosentetik yolağında alfa-aminoadipat dehidrojenazın etkinleşmesi için gerekli olan Saccharomyces cerevisiae LYS5'e benzer. Maya alfa-aminoadipat dehidrojenazı; alfa-biyosentetik-aminoadipat semialdehiti, alfa-aminoadipata dönüştürür. İnsan genindeki bozuklukların pipekolik asidemiye neden olduğu ileri sürülmüştür.^[6]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149313 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity". J Biol Chem. 278 (35). Aug 2003. ss. 33142-9.
^ "Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene". Mol Genet Metab. 72 (4). Apr 2001. ss. 336-42.
^ ^a ^b "Entrez Gene: AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

Konuyla ilgili yayınlar

"Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). 2005. ss. 1173-8.
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). 2004. ss. 2121-7.
Mammalian Gene Collection Program Team (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26). ss. 16899-16903.
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10). 2001. ss. 1546-60.
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17). 2000. ss. 9543-8.
"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5). 2000. ss. 703-13.

Dış bağlantılar

AASDHPPT 10 Mayıs 2017 tarihinde Wayback Machine sitesinde arşivlendi. human gene location in the UCSC Genome Browser.
AASDHPPT 10 Mayıs 2017 tarihinde Wayback Machine sitesinde arşivlendi. human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149313 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12815048-4] "Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity". J Biol Chem. 278 (35). Aug 2003. ss. 33142-9.

[pmid11286508-5] "Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene". Mol Genet Metab. 72 (4). Apr 2001. ss. 336-42.

[entrez-6] "Entrez Gene: AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

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